DOT Medical Practice Exam 2025 – Complete Test Prep

Alprazolam is a benzodiazepine that is commonly used as a sedative and anxiolytic. Its mechanism of action enhances the effect of the neurotransmitter GABA in the brain, leading to sedative and tranquilizing effects. This can result in drowsiness, impaired coordination, and reduced alertness, which are significant factors that can compromise an individual’s ability to drive safely.

In contrast, metoprolol, sertraline, and duloxetine are not primarily sedative medications. Metoprolol is a beta-blocker used for heart conditions and does not typically impair cognitive or motor function in the same way that sedatives do. Sertraline is an antidepressant that may cause side effects but is generally not associated with significant sedation, especially in experienced users. Duloxetine, an antidepressant that also relieves pain, may cause drowsiness in some individuals, but it is not primarily classified as a sedative like alprazolam is.

Thus, among the options provided, alprazolam is distinctly recognized for its sedative properties, which pose a meaningful risk when it comes to activities requiring alertness, such as driving.